Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion

Mammalian and prokaryotic high-temperature requirement A (HtrA) proteins are chaperones and serine proteases with important roles in protein quality control. Here, we describe an entirely new function of HtrA and identify it as a new secreted virulence factor from Helicobacter pylori, which cleaves...

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Detalhes bibliográficos
Main Authors: Hoy, Benjamin, Löwer, Martin, Weydig, Christiane, Carra, Gert, Tegtmeyer, Nicole, Geppert, Tim, Schröder, Peter, Sewald, Norbert, Backert, Steffen, Schneider, Gisbert, Wessler, Silja
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948180/
https://ncbi.nlm.nih.gov/pubmed/20814423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2010.114
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