Distinct Roles of Secreted HtrA Proteases from Gram-negative Pathogens in Cleaving the Junctional Protein and Tumor Suppressor E-cadherin

The periplasmic chaperone and serine protease HtrA is important for bacterial stress responses and protein quality control. Recently, we discovered that HtrA from Helicobacter pylori is secreted and cleaves E-cadherin to disrupt the epithelial barrier, but it remained unknown whether this maybe a ge...

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Détails bibliographiques
Auteurs principaux: Hoy, Benjamin, Geppert, Tim, Boehm, Manja, Reisen, Felix, Plattner, Patrick, Gadermaier, Gabriele, Sewald, Norbert, Ferreira, Fatima, Briza, Peter, Schneider, Gisbert, Backert, Steffen, Wessler, Silja
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2012
Sujets:
Microbiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323053/
https://ncbi.nlm.nih.gov/pubmed/22337879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C111.333419
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