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Inhibiting Helicobacter pylori HtrA protease by addressing a computationally predicted allosteric ligand binding site
Helicobacter pylori is associated with inflammatory diseases and can cause gastric cancer and mucosa-associated lymphoma. One of the bacterium’s key proteins is high temperature requirement A (HpHtrA) protein, an extracellular serine protease that cleaves E-cadherin of gastric epithelial cells, whic...
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| Publicado no: | Chem Sci |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4724879/ https://ncbi.nlm.nih.gov/pubmed/26819700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C4SC01443J |
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