Antitumor effect of afatinib, as a human epidermal growth factor receptor 2‐targeted therapy, in lung cancers harboring HER2 oncogene alterations

Human epidermal growth factor receptor 2 (HER2) is a member of the HER family of proteins containing four receptor tyrosine kinases. It plays an important role in the pathogenesis of certain human cancers. In non‐small‐cell lung cancer (NSCLC), HER2 amplification or mutations have been reported. How...

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Veröffentlicht in:Cancer Sci
Hauptverfasser: Suzawa, Ken, Toyooka, Shinichi, Sakaguchi, Masakiyo, Morita, Mizuki, Yamamoto, Hiromasa, Tomida, Shuta, Ohtsuka, Tomoaki, Watanabe, Mototsugu, Hashida, Shinsuke, Maki, Yuho, Soh, Junichi, Asano, Hiroaki, Tsukuda, Kazunori, Miyoshi, Shinichiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2015
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724821/
https://ncbi.nlm.nih.gov/pubmed/26545934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12845
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