Novel α-tubulin mutation disrupts neural development and tubulin proteostasis

Mutations in the microtubule cytoskeleton are linked to cognitive and locomotor defects during development, and neurodegeneration in adults. How these mutations impact microtubules, and how this alters function at the level of neurons is an important area of investigation. Using a forward genetic sc...

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Bibliographic Details
Published in:Dev Biol
Main Authors: Hanson, Martin G., Aiken, Jayne, Sietsema, Daniel V., Sept, David, Bates, Emily A., Niswander, Lee, Moore, Jeffrey K.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724489/
https://ncbi.nlm.nih.gov/pubmed/26658218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2015.11.022
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