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Causes of evolutionary rate variation among protein sites

It has long been recognized that certain sites within a protein, such as sites in the protein core or catalytic residues in enzymes, are more conserved than are other sites. However, our understanding of rate variation among sites remains surprisingly limited. Recent progress to address this include...

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Bibliographic Details
Published in:Nat Rev Genet
Main Authors: Echave, Julian, Spielman, Stephanie J., Wilke, Claus O.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724262/
https://ncbi.nlm.nih.gov/pubmed/26781812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrg.2015.18
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