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Causes of evolutionary rate variation among protein sites

It has long been recognized that certain sites within a protein, such as sites in the protein core or catalytic residues in enzymes, are more conserved than are other sites. However, our understanding of rate variation among sites remains surprisingly limited. Recent progress to address this include...

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Библиографические подробности
Опубликовано в: :Nat Rev Genet
Главные авторы: Echave, Julian, Spielman, Stephanie J., Wilke, Claus O.
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724262/
https://ncbi.nlm.nih.gov/pubmed/26781812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrg.2015.18
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