A Viral microRNA Cluster Regulates the Expression of PTEN, p27 and of a bcl-2 Homolog

The Epstein-Barr virus (EBV) infects and transforms B-lymphocytes with high efficiency. This process requires expression of the viral latent proteins and of the 3 miR-BHRF1 microRNAs. Here we show that B-cells infected by a virus that lacks these non-coding RNAs (Δ123) grew more slowly between day 5...

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Bibliografiske detaljer
Udgivet i:PLoS Pathog
Main Authors: Bernhardt, Katharina, Haar, Janina, Tsai, Ming-Han, Poirey, Remy, Feederle, Regina, Delecluse, Henri-Jacques
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4723338/
https://ncbi.nlm.nih.gov/pubmed/26800049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005405
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