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Molecular Dissection of Induced Platinum Resistance through Functional and Gene Expression Analysis in a Cell Culture Model of Bladder Cancer

We report herein the development, functional and molecular characterization of an isogenic, paired bladder cancer cell culture model system for studying platinum drug resistance. The 5637 human bladder cancer cell line was cultured over ten months with stepwise increases in oxaliplatin concentration...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Wang, Sisi, Zhang, Hongyong, Scharadin, Tiffany M., Zimmermann, Maike, Hu, Bin, Pan, Amy Wang, Vinall, Ruth, Lin, Tzu-yin, Cimino, George, Chain, Patrick, Vuyisich, Momchilo, Gleasner, Cheryl, Mcmurry, Kim, Malfatti, Michael, Turteltaub, Kenneth, de Vere White, Ralph, Pan, Chong-xian, Henderson, Paul T.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4723083/
https://ncbi.nlm.nih.gov/pubmed/26799320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146256
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