The residue I257 at S4–S5 linker in KCNQ1 determines KCNQ1/KCNE1 channel sensitivity to 1-alkanols

AIM: KCNQ1 and KCNE1 form a complex in human ventricular cardiomyocytes, which are important in maintaining a normal heart rhythm. In the present study we investigated the effects of a homologous series of 1-alkanols on KCNQ1/KCNE1 channels expressed in Xenopus oocytes. METHODS: ECG recording was ma...

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Bibliographic Details
Published in:Acta Pharmacol Sin
Main Authors: Xie, Chang, Liu, Hao-wen, Pan, Na, Ding, Jiu-ping, Yao, Jing
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722973/
https://ncbi.nlm.nih.gov/pubmed/26725740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2015.133
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