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The residue I257 at S4–S5 linker in KCNQ1 determines KCNQ1/KCNE1 channel sensitivity to 1-alkanols
AIM: KCNQ1 and KCNE1 form a complex in human ventricular cardiomyocytes, which are important in maintaining a normal heart rhythm. In the present study we investigated the effects of a homologous series of 1-alkanols on KCNQ1/KCNE1 channels expressed in Xenopus oocytes. METHODS: ECG recording was ma...
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| Publicado no: | Acta Pharmacol Sin |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4722973/ https://ncbi.nlm.nih.gov/pubmed/26725740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2015.133 |
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