Identification of a Conformational Equilibrium That Determines the Efficacy and Functional Selectivity of the μ-Opioid Receptor

G-protein-coupled receptor (GPCR) ligands impart differing degrees of signaling in the G-protein and arrestin pathways, in phenomena called “biased signaling”. However, the mechanism underlying the biased signaling of GPCRs is still unclear, although crystal structures of GPCRs bound to the G protei...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Angew Chem Int Ed Engl
Hauptverfasser: Okude, Junya, Ueda, Takumi, Kofuku, Yutaka, Sato, Motohiko, Nobuyama, Naoyuki, Kondo, Keita, Shiraishi, Yutaro, Mizumura, Takuya, Onishi, Kento, Natsume, Mei, Maeda, Masahiro, Tsujishita, Hideki, Kuranaga, Takefumi, Inoue, Masayuki, Shimada, Ichio
Format: Artigo
Sprache:Inglês
Veröffentlicht: WILEY-VCH Verlag 2015
Schlagworte:
Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722849/
https://ncbi.nlm.nih.gov/pubmed/26568421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201508794
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