Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis

BACKGROUND: Mutations in the fused in sarcoma (FUS) gene have been linked to amyotrophic lateral sclerosis (ALS). ALS patients with FUS mutations exhibit neuronal cytoplasmic mislocalization of the mutant FUS protein. ALS patients’ fibroblasts or induced pluripotent stem cell (iPSC)-derived neurons...

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Detaylı Bibliyografya
Yayımlandı:Mol Neurodegener
Asıl Yazarlar: Lim, Su Min, Choi, Won Jun, Oh, Ki-Wook, Xue, Yuanchao, Choi, Ji Young, Kim, Sung Hoon, Nahm, Minyeop, Kim, Young-Eun, Lee, Jinhyuk, Noh, Min-Young, Lee, Seungbok, Hwang, Sejin, Ki, Chang-Seok, Fu, Xiang-Dong, Kim, Seung Hyun
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2016
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722778/
https://ncbi.nlm.nih.gov/pubmed/26795035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0075-6
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