Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis

BACKGROUND: Mutations in the fused in sarcoma (FUS) gene have been linked to amyotrophic lateral sclerosis (ALS). ALS patients with FUS mutations exhibit neuronal cytoplasmic mislocalization of the mutant FUS protein. ALS patients’ fibroblasts or induced pluripotent stem cell (iPSC)-derived neurons...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Neurodegener
Prif Awduron: Lim, Su Min, Choi, Won Jun, Oh, Ki-Wook, Xue, Yuanchao, Choi, Ji Young, Kim, Sung Hoon, Nahm, Minyeop, Kim, Young-Eun, Lee, Jinhyuk, Noh, Min-Young, Lee, Seungbok, Hwang, Sejin, Ki, Chang-Seok, Fu, Xiang-Dong, Kim, Seung Hyun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2016
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722778/
https://ncbi.nlm.nih.gov/pubmed/26795035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0075-6
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