Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis

BACKGROUND: Mutations in the fused in sarcoma (FUS) gene have been linked to amyotrophic lateral sclerosis (ALS). ALS patients with FUS mutations exhibit neuronal cytoplasmic mislocalization of the mutant FUS protein. ALS patients’ fibroblasts or induced pluripotent stem cell (iPSC)-derived neurons...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Neurodegener
Main Authors: Lim, Su Min, Choi, Won Jun, Oh, Ki-Wook, Xue, Yuanchao, Choi, Ji Young, Kim, Sung Hoon, Nahm, Minyeop, Kim, Young-Eun, Lee, Jinhyuk, Noh, Min-Young, Lee, Seungbok, Hwang, Sejin, Ki, Chang-Seok, Fu, Xiang-Dong, Kim, Seung Hyun
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2016
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722778/
https://ncbi.nlm.nih.gov/pubmed/26795035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0075-6
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki