The effect of 5-fluorouracil/leucovorin chemotherapy on CpG methylation, or the confounding role of leukocyte heterogeneity: an illustration

Blood-based epigenome-wide association studies that aim at comparing CpG methylation between colorectal cancer (CRC) patients and controls can lead to the discovery of diagnostic or prognostic biomarkers. Numerous confounders can lead to spurious associations. We aimed to see if 5-fluorouracil (5-FU...

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Bibliographic Details
Published in:Genomics
Main Authors: Lemire, Mathieu, Zaidi, Syed H.E., Zanke, Brent W., Gallinger, Steven, Hudson, Thomas J., Cleary, Sean P.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722538/
https://ncbi.nlm.nih.gov/pubmed/26368860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygeno.2015.09.003
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