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The effect of 5-fluorouracil/leucovorin chemotherapy on CpG methylation, or the confounding role of leukocyte heterogeneity: an illustration

Blood-based epigenome-wide association studies that aim at comparing CpG methylation between colorectal cancer (CRC) patients and controls can lead to the discovery of diagnostic or prognostic biomarkers. Numerous confounders can lead to spurious associations. We aimed to see if 5-fluorouracil (5-FU...

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Detalhes bibliográficos
Publicado no:Genomics
Main Authors: Lemire, Mathieu, Zaidi, Syed H.E., Zanke, Brent W., Gallinger, Steven, Hudson, Thomas J., Cleary, Sean P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722538/
https://ncbi.nlm.nih.gov/pubmed/26368860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygeno.2015.09.003
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