Loss of G(s)α in the Postnatal Skeleton Leads to Low Bone Mass and a Blunted Response to Anabolic Parathyroid Hormone Therapy

Parathyroid hormone (PTH) is an important regulator of osteoblast function and is the only anabolic therapy currently approved for treatment of osteoporosis. The PTH receptor (PTH1R) is a G protein-coupled receptor that signals via multiple G proteins including G(s)α. Mice expressing a constitutivel...

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Pubblicato in:J Biol Chem
Autori principali: Sinha, Partha, Aarnisalo, Piia, Chubb, Rhiannon, Poulton, Ingrid J., Guo, Jun, Nachtrab, Gregory, Kimura, Takaharu, Swami, Srilatha, Saeed, Hamid, Chen, Min, Weinstein, Lee S., Schipani, Ernestina, Sims, Natalie A., Kronenberg, Henry M., Wu, Joy Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2016
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722446/
https://ncbi.nlm.nih.gov/pubmed/26598522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.679753
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