Loss of G(s)α in the Postnatal Skeleton Leads to Low Bone Mass and a Blunted Response to Anabolic Parathyroid Hormone Therapy

Parathyroid hormone (PTH) is an important regulator of osteoblast function and is the only anabolic therapy currently approved for treatment of osteoporosis. The PTH receptor (PTH1R) is a G protein-coupled receptor that signals via multiple G proteins including G(s)α. Mice expressing a constitutivel...

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Publicado en:J Biol Chem
Autores principales: Sinha, Partha, Aarnisalo, Piia, Chubb, Rhiannon, Poulton, Ingrid J., Guo, Jun, Nachtrab, Gregory, Kimura, Takaharu, Swami, Srilatha, Saeed, Hamid, Chen, Min, Weinstein, Lee S., Schipani, Ernestina, Sims, Natalie A., Kronenberg, Henry M., Wu, Joy Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722446/
https://ncbi.nlm.nih.gov/pubmed/26598522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.679753
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