Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo

Chemokines are required for leukocyte recruitment and appropriate host defense and act through G protein-coupled receptors (GPCRs), which induce downstream signaling leading to integrin activation. Although the α and β subunits of the GPCRs are the first intracellular molecules that transduce signal...

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Bibliographic Details
Published in:Blood
Main Authors: Block, Helena, Stadtmann, Anika, Riad, Daniel, Rossaint, Jan, Sohlbach, Charlotte, Germena, Giulia, Wu, Dianqing, Simon, Scott I., Ley, Klaus, Zarbock, Alexander
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2016
Subjects:
Immunobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722285/
https://ncbi.nlm.nih.gov/pubmed/26468229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-06-651034
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