Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography

Determining the interconverting conformations of dynamic proteins in atomic detail is a major challenge for structural biology. Conformational heterogeneity in the active site of the dynamic enzyme cyclophilin A (CypA) has been previously linked to its catalytic function, but the extent to which the...

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הוצא לאור ב:eLife
Main Authors: Keedy, Daniel A, Kenner, Lillian R, Warkentin, Matthew, Woldeyes, Rahel A, Hopkins, Jesse B, Thompson, Michael C, Brewster, Aaron S, Van Benschoten, Andrew H, Baxter, Elizabeth L, Uervirojnangkoorn, Monarin, McPhillips, Scott E, Song, Jinhu, Alonso-Mori, Roberto, Holton, James M, Weis, William I, Brunger, Axel T, Soltis, S Michael, Lemke, Henrik, Gonzalez, Ana, Sauter, Nicholas K, Cohen, Aina E, van den Bedem, Henry, Thorne, Robert E, Fraser, James S
פורמט: Artigo
שפה:Inglês
יצא לאור: eLife Sciences Publications, Ltd 2015
נושאים:
Biophysics and Structural Biology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4721965/
https://ncbi.nlm.nih.gov/pubmed/26422513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07574
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