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Journey to the center of the protein: allostery from multitemperature multiconformer X-ray crystallography

Proteins inherently fluctuate between conformations to perform functions in the cell. For example, they sample product-binding, transition-state-stabilizing and product-release states during catalysis, and they integrate signals from remote regions of the structure for allosteric regulation. However...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Acta Crystallogr D Struct Biol
Prif Awdur: Keedy, Daniel A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: International Union of Crystallography 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400254/
https://ncbi.nlm.nih.gov/pubmed/30821702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798318017941
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