The CUL4-DDB1 ubiquitin ligase complex controls adult and embryonic stem cell differentiation and homeostasis

Little is known on post-transcriptional regulation of adult and embryonic stem cell maintenance and differentiation. Here we characterize the role of Ddb1, a component of the CUL4-DDB1 ubiquitin ligase complex. Ddb1 is highly expressed in multipotent hematopoietic progenitors and its deletion leads...

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Pubblicato in:eLife
Autori principali: Gao, Jie, Buckley, Shannon M, Cimmino, Luisa, Guillamot, Maria, Strikoudis, Alexandros, Cang, Yong, Goff, Stephen P, Aifantis, Iannis
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2015
Soggetti:
Developmental Biology and Stem Cells
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4721963/
https://ncbi.nlm.nih.gov/pubmed/26613412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07539
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