Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2)

BACKGROUND: Triggering receptor expressed on myeloid cells-2 (TREM2) exerts important functions in the regulation of monocytes, like dendritic cells, osteoclasts, tissue macrophages, and microglia. Mutations in TREM2 are associated with several diseases, including Nasu-Hakola disease, frontotemporal...

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Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Glebov, Konstantin, Wunderlich, Patrick, Karaca, Ilker, Walter, Jochen
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Short Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4721188/
https://ncbi.nlm.nih.gov/pubmed/26792193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0479-9
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