Sequential Proteolytic Processing of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Protein by Ectodomain Shedding and γ-Secretase-dependent Intramembranous Cleavage

Triggering receptor expressed on myeloid cells-2 (TREM2) and its signaling adaptor protein TYROBP/DAP12 play important roles in signal transduction in dendritic cells, osteoclasts, tissue macrophages, and microglia. Recently, TREM2 variants have been shown to be linked to late onset Alzheimer diseas...

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Detalhes bibliográficos
Main Authors: Wunderlich, Patrick, Glebov, Konstantin, Kemmerling, Nadja, Tien, Nguyen T., Neumann, Harald, Walter, Jochen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829152/
https://ncbi.nlm.nih.gov/pubmed/24078628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.517540
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