Estrogen receptor α in cancer associated fibroblasts suppresses prostate cancer invasion via reducing CCL5, IL6 and macrophage infiltration in the tumor microenvironment

BACKGROUND: Cancer associated fibroblasts (CAF) play important roles in tumor growth that involves inflammation and epithelial cell differentiation. Early studies suggested that estrogen receptor alpha (ERα) was expressed in stromal cells in normal prostates and prostate cancer (PCa), but the detail...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Cancer
Main Authors: Yeh, Chiuan-Ren, Slavin, Spencer, Da, Jun, Hsu, Iawen, Luo, Jie, Xiao, Guang-Qian, Ding, Jie, Chou, Fu-Ju, Yeh, Shuyuan
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2016
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4721150/
https://ncbi.nlm.nih.gov/pubmed/26790618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0488-9
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