Estrogen receptor α in cancer associated fibroblasts suppresses prostate cancer invasion via reducing CCL5, IL6 and macrophage infiltration in the tumor microenvironment

BACKGROUND: Cancer associated fibroblasts (CAF) play important roles in tumor growth that involves inflammation and epithelial cell differentiation. Early studies suggested that estrogen receptor alpha (ERα) was expressed in stromal cells in normal prostates and prostate cancer (PCa), but the detail...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Yeh, Chiuan-Ren, Slavin, Spencer, Da, Jun, Hsu, Iawen, Luo, Jie, Xiao, Guang-Qian, Ding, Jie, Chou, Fu-Ju, Yeh, Shuyuan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4721150/
https://ncbi.nlm.nih.gov/pubmed/26790618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0488-9
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