Estrogen receptor α in cancer-associated fibroblasts suppresses prostate cancer invasion via modulation of thrombospondin 2 and matrix metalloproteinase 3

The prostate cancer (PCa) microenvironment contains active stromal cells known as cancer-associated fibroblasts (CAF) that may play important roles in influencing tumor progression. Here we studied the role of CAF estrogen receptor alpha (ERα) and found that it could protect against PCa invasion. Im...

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Bibliographic Details
Main Authors: Slavin, Spencer, Yeh, Chiuan-Ren, Da, Jun, Yu, Shengqiang, Miyamoto, Hiroshi, Messing, Edward M., Guancial, Elizabeth, Yeh, Shuyuan
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4043239/
https://ncbi.nlm.nih.gov/pubmed/24374826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgt488
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