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An in vivo platform for identifying inhibitors of protein aggregation
Protein aggregation underlies an array of human diseases, yet only one small molecule therapeutic has been successfully developed to date. Here, we introduce an in vivo system, based on a β-lactamase tripartite fusion construct, capable of identifying aggregation-prone sequences in the periplasm of...
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| Publicado en: | Nat Chem Biol |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4720988/ https://ncbi.nlm.nih.gov/pubmed/26656088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1988 |
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