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Insights into the consequences of co-polymerisation in the early stages of IAPP and Aβ peptide assembly from mass spectrometry

The precise molecular mechanisms by which different peptides and proteins assemble into highly ordered amyloid deposits remain elusive. The fibrillation of human amylin (also known as islet amyloid polypeptide, hIAPP) and the amyloid-beta peptide (Aβ-40) are thought to be pathogenic factors in Type...

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Detalles Bibliográficos
Publicado en:Analyst
Main Authors: Young, Lydia M., Mahood, Rachel A., Saunders, Janet C., Tu, Ling-Hsien, Raleigh, Daniel P., Radford, Sheena E., Ashcroft, Alison E.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4626081/
https://ncbi.nlm.nih.gov/pubmed/26193839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5an00865d
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