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An in vivo platform for identifying inhibitors of protein aggregation

Protein aggregation underlies an array of human diseases, yet only one small molecule therapeutic has been successfully developed to date. Here, we introduce an in vivo system, based on a β-lactamase tripartite fusion construct, capable of identifying aggregation-prone sequences in the periplasm of...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Saunders, Janet C., Young, Lydia M., Mahood, Rachel A., Jackson, Matthew P., Revill, Charlotte H., Foster, Richard J., Smith, D. Alastair, Ashcroft, Alison E., Brockwell, David J., Radford, Sheena E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720988/
https://ncbi.nlm.nih.gov/pubmed/26656088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1988
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