An in vivo platform for identifying inhibitors of protein aggregation

Protein aggregation underlies an array of human diseases, yet only one small molecule therapeutic has been successfully developed to date. Here, we introduce an in vivo system, based on a β-lactamase tripartite fusion construct, capable of identifying aggregation-prone sequences in the periplasm of...

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Veröffentlicht in:Nat Chem Biol
Hauptverfasser: Saunders, Janet C., Young, Lydia M., Mahood, Rachel A., Jackson, Matthew P., Revill, Charlotte H., Foster, Richard J., Smith, D. Alastair, Ashcroft, Alison E., Brockwell, David J., Radford, Sheena E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720988/
https://ncbi.nlm.nih.gov/pubmed/26656088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1988
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