Inadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/p97

The cellular mechanisms that control protein degradation may constitute a non-oncogenic cancer cell vulnerability and, therefore, a therapeutic target. Although this proposition is supported by the clinical success of proteasome inhibitors in some malignancies, most cancers are resistant to proteaso...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cell Death Dis
Hlavní autoři: Parzych, K, Chinn, T M, Chen, Z, Loaiza, S, Porsch, F, Valbuena, G N, Kleijnen, M F, Karadimitris, A, Gentleman, E, Keun, H C, Auner, H W
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720905/
https://ncbi.nlm.nih.gov/pubmed/26720340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.373
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky