Effects of PI3K inhibitor NVP-BKM120 on overcoming drug resistance and eliminating cancer stem cells in human breast cancer cells

The multidrug resistance (MDR) phenotype often accompanies activation of the phosphatidylinositol 3-kinase (PI3K)/AKT pathway, which renders a survival signal to withstand cytotoxic anticancer drugs and enhances cancer stem cell (CSC) characteristics. As a result, PI3K/AKT-blocking approaches have b...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Hu, Y, Guo, R, Wei, J, Zhou, Y, Ji, W, Liu, J, Zhi, X, Zhang, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720896/
https://ncbi.nlm.nih.gov/pubmed/26673665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.363
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