Targeting RING domains of Mdm2–MdmX E3 complex activates apoptotic arm of the p53 pathway in leukemia/lymphoma cells

Reactivation of tumor-suppressor p53 for targeted cancer therapy is an attractive strategy for cancers bearing wild-type (WT) p53. Targeting the Mdm2–p53 interface or MdmX ((MDM4), mouse double minute 4)–p53 interface or both has been a focus in the field. However, targeting the E3 ligase activity o...

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Publicat a:Cell Death Dis
Autors principals: Wu, W, Xu, C, Ling, X, Fan, C, Buckley, B P, Chernov, M V, Ellis, L, Li, F, Muñoz, I G, Wang, X
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720891/
https://ncbi.nlm.nih.gov/pubmed/26720344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.358
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