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Transcriptional enhancers: functional insights and role in human disease

In recent years, studies of cis-regulatory mechanisms have evolved from a predominant focus on promoter regions to the realization that spatial and temporal gene regulation is frequently driven by long-range enhancer clusters that operate within chromosomal compartments. This increased understanding...

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Bibliographische Detailangaben
Veröffentlicht in:Curr Opin Genet Dev
Hauptverfasser: Miguel-Escalada, Irene, Pasquali, Lorenzo, Ferrer, Jorge
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720706/
https://ncbi.nlm.nih.gov/pubmed/26433090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gde.2015.08.009
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