Chronic Treatment with the AMPK Agonist AICAR Prevents Skeletal Muscle Pathology but Fails to Improve Clinical Outcome in a Mouse Model of Severe Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is a genetic neuromuscular disorder characterized by spinal and brainstem motor neuron (MN) loss and skeletal muscle paralysis. Currently, there is no effective treatment other than supportive care to ameliorate the quality of life of patients with SMA. Some studies hav...

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Bibliografiska uppgifter
I publikationen:Neurotherapeutics
Huvudupphovsmän: Cerveró, Clàudia, Montull, Neus, Tarabal, Olga, Piedrafita, Lídia, Esquerda, Josep E., Calderó, Jordi
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer US 2015
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Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720671/
https://ncbi.nlm.nih.gov/pubmed/26582176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-015-0399-x
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