Chronic Treatment with the AMPK Agonist AICAR Prevents Skeletal Muscle Pathology but Fails to Improve Clinical Outcome in a Mouse Model of Severe Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is a genetic neuromuscular disorder characterized by spinal and brainstem motor neuron (MN) loss and skeletal muscle paralysis. Currently, there is no effective treatment other than supportive care to ameliorate the quality of life of patients with SMA. Some studies hav...

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Detalhes bibliográficos
Publicado no:Neurotherapeutics
Main Authors: Cerveró, Clàudia, Montull, Neus, Tarabal, Olga, Piedrafita, Lídia, Esquerda, Josep E., Calderó, Jordi
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720671/
https://ncbi.nlm.nih.gov/pubmed/26582176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-015-0399-x
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