Chronic Treatment with the AMPK Agonist AICAR Prevents Skeletal Muscle Pathology but Fails to Improve Clinical Outcome in a Mouse Model of Severe Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is a genetic neuromuscular disorder characterized by spinal and brainstem motor neuron (MN) loss and skeletal muscle paralysis. Currently, there is no effective treatment other than supportive care to ameliorate the quality of life of patients with SMA. Some studies hav...

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Vydáno v:Neurotherapeutics
Hlavní autoři: Cerveró, Clàudia, Montull, Neus, Tarabal, Olga, Piedrafita, Lídia, Esquerda, Josep E., Calderó, Jordi
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2015
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720671/
https://ncbi.nlm.nih.gov/pubmed/26582176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-015-0399-x
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