Neutralizing Monoclonal Antibodies Block Chikungunya Virus Entry and Release by Targeting an Epitope Critical to Viral Pathogenesis

We evaluated the mechanism by which neutralizing human monoclonal antibodies inhibit chikungunya virus (CHIKV) infection. Potently neutralizing antibodies (NAbs) blocked infection at multiple steps of the virus life cycle, including entry and release. Cryo-electron microscopy structures of Fab fragm...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Jin, Jing, Liss, Nathan M., Chen, Dong-Hua, Liao, Maofu, Fox, Julie M., Shimak, Raeann M., Fong, Rachel H., Chafets, Daniel, Bakkour, Sonia, Keating, Sheila, Fomin, Marina E., Muench, Marcus O., Sherman, Michael B., Doranz, Benjamin J., Diamond, Michael S., Simmons, Graham
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720387/
https://ncbi.nlm.nih.gov/pubmed/26686638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.11.043
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