A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9

Clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas)9 genomic editing has revolutionized the generation of mutant animals by simplifying the creation of null alleles in virtually any organism. However, most current approaches with this method require zygote injection,...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Carroll, Kelli J., Makarewich, Catherine A., McAnally, John, Anderson, Douglas M., Zentilin, Lorena, Liu, Ning, Giacca, Mauro, Bassel-Duby, Rhonda, Olson, Eric N.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720342/
https://ncbi.nlm.nih.gov/pubmed/26719419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523918113
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