A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9

Clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas)9 genomic editing has revolutionized the generation of mutant animals by simplifying the creation of null alleles in virtually any organism. However, most current approaches with this method require zygote injection,...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Carroll, Kelli J., Makarewich, Catherine A., McAnally, John, Anderson, Douglas M., Zentilin, Lorena, Liu, Ning, Giacca, Mauro, Bassel-Duby, Rhonda, Olson, Eric N.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720342/
https://ncbi.nlm.nih.gov/pubmed/26719419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523918113
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