An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response

Inhibitors of the HIV aspartyl protease [HIV protease inhibitors (HIV-PIs)] are the cornerstone of treatment for HIV. Beyond their well-defined antiretroviral activity, these drugs have additional effects that modulate cell viability and homeostasis. However, little is known about the virus-independ...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: De Gassart, Aude, Bujisic, Bojan, Zaffalon, Léa, Decosterd, Laurent A., Di Micco, Antonia, Frera, Gianluca, Tallant, Rémy, Martinon, Fabio
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720296/
https://ncbi.nlm.nih.gov/pubmed/26715744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514076113
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