Rif1 Maintains Telomere Length Homeostasis of ESCs by Mediating Heterochromatin Silencing

Telomere length homeostasis is essential for genomic stability and unlimited self-renewal of embryonic stem cells (ESCs). We show that telomere-associated protein Rif1 is required to maintain telomere length homeostasis by negatively regulating Zscan4 expression, a critical factor for telomere elong...

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Pubblicato in:Dev Cell
Autori principali: Dan, Jiameng, Liu, Yifei, Liu, Na, Chiourea, Maria, Okuka, Maja, Wu, Tao, Ye, Xiaoying, Mou, Chunlin, Wang, Lei, Wang, Lingling, Yin, Yu, Yuan, Jihong, Zuo, Bingfeng, Wang, Fang, Li, Zhiguo, Pan, Xinghua, Yin, Zhinan, Chen, Lingyi, Keefe, David L., Gagos, Sarantis, Xiao, Andrew, Liu, Lin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720134/
https://ncbi.nlm.nih.gov/pubmed/24735877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2014.03.004
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