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The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression
The KEAP1-NRF2 system plays a central role in cytoprotection. NRF2 is stabilized in response to electrophiles and activates transcription of antioxidant genes. Although robust induction of NRF2 target genes confers resistance to oxidative insults, how NRF2 triggers transcriptional activation after b...
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| Publicado no: | Mol Cell Biol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4719425/ https://ncbi.nlm.nih.gov/pubmed/26572828 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00785-15 |
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