Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2

NRF2 (nuclear factor erythroid 2-related factor 2) is a key transcriptional activator that mediates the inducible expression of antioxidant genes. NRF2 is normally ubiquitinated by KEAP1 (Kelch-like ECH-associated protein 1) and subsequently degraded by proteasomes. Inactivation of KEAP1 by oxidativ...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Alam, Md. Morshedul, Okazaki, Keito, Nguyen, Linh Thi Thao, Ota, Nao, Kitamura, Hiroshi, Murakami, Shohei, Shima, Hiroki, Igarashi, Kazuhiko, Sekine, Hiroki, Motohashi, Hozumi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2017
Gaiak:
Gene Regulation
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418050/
https://ncbi.nlm.nih.gov/pubmed/28314773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.773960
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