A PTIP–PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex

Class switch recombination (CSR) diversifies antibodies for productive immune responses while maintaining stability of the B-cell genome. Transcription at the immunoglobulin heavy chain (Igh) locus targets CSR-associated DNA damage and is promoted by the BRCT domain-containing PTIP (Pax transactivat...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Starnes, Linda M., Su, Dan, Pikkupeura, Laura M., Weinert, Brian T., Santos, Margarida A., Mund, Andreas, Soria, Rebeca, Cho, Young-Wook, Pozdnyakova, Irina, Kubec Højfeldt, Martina, Vala, Andrea, Yang, Wenjing, López-Méndez, Blanca, Lee, Ji-Eun, Peng, Weiqun, Yuan, Joan, Ge, Kai, Montoya, Guillermo, Nussenzweig, André, Choudhary, Chunaram, Daniel, Jeremy A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719306/
https://ncbi.nlm.nih.gov/pubmed/26744420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.268797.115
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