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PTIP Promotes Chromatin Changes Critical for Immunoglobulin Class Switch Recombination
Programmed genetic rearrangements in lymphocytes require transcription at antigen receptor genes to promote accessibility for initiating double-strand break (DSB) formation critical for DNA recombination and repair. Here, we showed that activated B cells deficient in the PTIP component of the MLL3 (...
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主要な著者: | , , , , , , , , , , , , , , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
2010
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3008398/ https://ncbi.nlm.nih.gov/pubmed/20671152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1187942 |
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