PTIP Promotes Chromatin Changes Critical for Immunoglobulin Class Switch Recombination

Programmed genetic rearrangements in lymphocytes require transcription at antigen receptor genes to promote accessibility for initiating double-strand break (DSB) formation critical for DNA recombination and repair. Here, we showed that activated B cells deficient in the PTIP component of the MLL3 (...

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Detalhes bibliográficos
Main Authors: Daniel, Jeremy A., Santos, Margarida Almeida, Wang, Zhibin, Zang, Chongzhi, Schwab, Kristopher R., Jankovic, Mila, Filsuf, Darius, Chen, Hua-Tang, Gazumyan, Anna, Yamane, Arito, Cho, Young-Wook, Sun, Hong-Wei, Ge, Kai, Peng, Weiqun, Nussenzweig, Michel C., Casellas, Rafael, Dressler, Gregory R., Zhao, Keji, Nussenzweig, André
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3008398/
https://ncbi.nlm.nih.gov/pubmed/20671152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1187942
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