Human Engineered Cardiac Tissues Created Using Induced Pluripotent Stem Cells Reveal Functional Characteristics of BRAF-Mediated Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is a leading cause of sudden cardiac death that often goes undetected in the general population. HCM is also prevalent in patients with cardio-facio-cutaneous syndrome (CFCS), which is a genetic disorder characterized by aberrant signaling in the RAS/MAPK signaling...

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Detalles Bibliográficos
Publicado en:PLoS One
Autores principales: Cashman, Timothy J., Josowitz, Rebecca, Johnson, Bryce V., Gelb, Bruce D., Costa, Kevin D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718533/
https://ncbi.nlm.nih.gov/pubmed/26784941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146697
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