Monoclonal Antibodies That Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel)

[Image: see text] The singular structure of artemisinin, with its embedded 1,2,4-trioxane heterocycle, has inspired the discovery of numerous semisynthetic artemisinin and structurally diverse synthetic peroxide antimalarials, including ozonides OZ277 (arterolane) and OZ439 (artefenomel). Despite th...

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Pubblicato in:ACS Infect Dis
Autori principali: Jourdan, Joëlle, Matile, Hugues, Reift, Ellen, Biehlmaier, Oliver, Dong, Yuxiang, Wang, Xiaofang, Mäser, Pascal, Vennerstrom, Jonathan L., Wittlin, Sergio
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2015
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718528/
https://ncbi.nlm.nih.gov/pubmed/26819968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.5b00090
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