Subtelomeric p53 binding prevents accumulation of DNA damage at human telomeres

Telomeres and tumor suppressor protein TP53 (p53) function in genome protection, but a direct role of p53 at telomeres has not yet been described. Here, we have identified non‐canonical p53‐binding sites within the human subtelomeres that suppress the accumulation of DNA damage at telomeric repeat D...

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Vydáno v:EMBO J
Hlavní autoři: Tutton, Stephen, Azzam, Greggory A, Stong, Nicholas, Vladimirova, Olga, Wiedmer, Andreas, Monteith, Jessica A, Beishline, Kate, Wang, Zhuo, Deng, Zhong, Riethman, Harold, McMahon, Steven B, Murphy, Maureen, Lieberman, Paul M
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2015
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718461/
https://ncbi.nlm.nih.gov/pubmed/26658110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490880
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