Subtelomeric p53 binding prevents accumulation of DNA damage at human telomeres

Telomeres and tumor suppressor protein TP53 (p53) function in genome protection, but a direct role of p53 at telomeres has not yet been described. Here, we have identified non‐canonical p53‐binding sites within the human subtelomeres that suppress the accumulation of DNA damage at telomeric repeat D...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Tutton, Stephen, Azzam, Greggory A, Stong, Nicholas, Vladimirova, Olga, Wiedmer, Andreas, Monteith, Jessica A, Beishline, Kate, Wang, Zhuo, Deng, Zhong, Riethman, Harold, McMahon, Steven B, Murphy, Maureen, Lieberman, Paul M
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718461/
https://ncbi.nlm.nih.gov/pubmed/26658110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490880
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