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TDP‐43 loss of function increases TFEB activity and blocks autophagosome–lysosome fusion
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is characterized by selective loss of motor neurons in brain and spinal cord. TAR DNA‐binding protein 43 (TDP‐43) was identified as a major component of disease pathogenesis in ALS, frontotemporal lobar degeneration (FTLD)...
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4718457/ https://ncbi.nlm.nih.gov/pubmed/26702100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201591998 |
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