TDP‐43 loss of function increases TFEB activity and blocks autophagosome–lysosome fusion

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is characterized by selective loss of motor neurons in brain and spinal cord. TAR DNA‐binding protein 43 (TDP‐43) was identified as a major component of disease pathogenesis in ALS, frontotemporal lobar degeneration (FTLD)...

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Dades bibliogràfiques
Publicat a:EMBO J
Autors principals: Xia, Qin, Wang, Hongfeng, Hao, Zongbing, Fu, Cheng, Hu, Qingsong, Gao, Feng, Ren, Haigang, Chen, Dong, Han, Junhai, Ying, Zheng, Wang, Guanghui
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718457/
https://ncbi.nlm.nih.gov/pubmed/26702100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201591998
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