Molecular cause and functional impact of altered synaptic lipid signaling due to a prg‐1 gene SNP

Loss of plasticity‐related gene 1 (PRG‐1), which regulates synaptic phospholipid signaling, leads to hyperexcitability via increased glutamate release altering excitation/inhibition (E/I) balance in cortical networks. A recently reported SNP in prg‐1 (R345T/mutPRG‐1) affects ~5 million European and...

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Vydáno v:EMBO Mol Med
Hlavní autoři: Vogt, Johannes, Yang, Jenq‐Wei, Mobascher, Arian, Cheng, Jin, Li, Yunbo, Liu, Xingfeng, Baumgart, Jan, Thalman, Carine, Kirischuk, Sergei, Unichenko, Petr, Horta, Guilherme, Radyushkin, Konstantin, Stroh, Albrecht, Richers, Sebastian, Sahragard, Nassim, Distler, Ute, Tenzer, Stefan, Qiao, Lianyong, Lieb, Klaus, Tüscher, Oliver, Binder, Harald, Ferreiros, Nerea, Tegeder, Irmgard, Morris, Andrew J, Gropa, Sergiu, Nürnberg, Peter, Toliat, Mohammad R, Winterer, Georg, Luhmann, Heiko J, Huai, Jisen, Nitsch, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2015
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718157/
https://ncbi.nlm.nih.gov/pubmed/26671989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201505677
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